| LOWER KEYS PIN-TO-WIN INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Mar 12, 2002 | Inactive |
| NO NAME KEY, INC.No Name Key, FL · Inactive | No Name Key, FL | Nonprofit | Aug 20, 2003 | Inactive |
| FLORIDA KEYS COMMUNITY HOUSING AND LAND TRUST, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Jun 2, 2004 | Inactive |
| SANCTUARY FRIENDS FOUNDATION OF THE KEYS, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Aug 9, 1984 | Inactive |
| BIG PINE COOPERATIVE PRESCHOOL, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Aug 30, 1984 | Inactive |
| PUNTA BRISA OWNERS' ASSOCIATION, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Nov 21, 2005 | Inactive |
| FL. KEYS, SEAHORSE PARK HOMEOWNERS ASSOCIATION, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Oct 26, 2007 | Inactive |
| ENVIRONMENTAL CONCERNED COMMERCIAL FISHERMAN OF THE LOWER KEYS INCBig Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Nov 1, 2007 | Inactive |
| PINE ACRES CONSERVATION ASSOCIATION INCORPORATEDBig Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Nov 5, 2007 | Inactive |
| FRIENDS OF WORLD DICTIONARY OF TREES SOCIETY INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Nov 30, 2007 | Inactive |
| NO NAME KEY PROPERTY OWNERS ASSOCIATION, INC.No Name Key Big Pine Key, FL · Inactive | No Name Key Big Pine Key, FL | Nonprofit | Aug 21, 2008 | Inactive |
| KEYS VINEYARD CHURCH, INC.Big Pine Key, FL · Active | Big Pine Key, FL | Nonprofit | Apr 17, 1985 | Active |
| ENVIRONMENTALLY CONCERNED COMMERCIAL DIVERS OF THE LOWER KEYS, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Jun 17, 2009 | Inactive |
| SAINT FRANCIS IN THE KEYS EPISCOPAL CHURCH, INCORPORATEDBig Pine Key, FL · Active | Big Pine Key, FL | Nonprofit | Jun 13, 1985 | Active |
| LIFE INDUSTRIES, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Jun 26, 1985 | Inactive |
| SHAMROCKS OF FLORIDA MC INCORPORATEDBig Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Mar 9, 2010 | Inactive |
| SECOND CHANCE ANIMAL RESCUE SOCIETY INC.Big Pine Jey, FL · Inactive | Big Pine Jey, FL | Nonprofit | Oct 4, 2010 | Inactive |
| LATIN AMERICAN MOTORCYCLE ASSOCIATION KEY WEST CHAPTER, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Jan 18, 2011 | Inactive |
| CARIBBEAN COUNCIL FOR ECONOMIC DEVELOPMENT INC.Lake Park, FL · Inactive | Lake Park, FL | Nonprofit | Aug 24, 2011 | Inactive |
| THE TEDDIE FOUNDATION INC.Big Pine, FL · Inactive | Big Pine, FL | Nonprofit | Nov 9, 2011 | Inactive |
| ORTHODOX MISSION OF THE FLORIDA KEYS, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Dec 19, 2011 | Inactive |
| AMERICAN PET ASSOCIATION SOCIETY FOR THE PROTECTION OF COMPANION ANIMALS INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Dec 30, 2011 | Inactive |
| BIG PINE KEY LIONS CLUB, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Jan 18, 2012 | Inactive |
| CHEROKEE GOURD GATHERING, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Feb 17, 2012 | Inactive |
| SPEC OP SCUBA, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | May 2, 2012 | Inactive |
| RYBO FITNESS INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Nov 12, 2013 | Inactive |
| APOSTOLIC PENTECOSTAL CHURCH OF JESUS CHRIST, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Feb 20, 1986 | Inactive |
| THE DICK AND BRENA PARSONS FOUNDATION, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Jan 21, 2014 | Inactive |
| BIG PINE KEY GUN RANGE, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Jun 26, 2014 | Inactive |
| FLORIDA KEYS SEAHORSE PARK HOMEOWNERS ASSOCIATION, INCBig Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Aug 14, 2014 | Inactive |
| MINISTERIO INTERNACIONAL VOZ DE VIDA, INC.Green Cove Springs, FL · Inactive | Green Cove Springs, FL | Nonprofit | Dec 4, 2014 | Inactive |
| KEY WEST SEA TURTLE CLUB INC.Big Pine, FL · Inactive | Big Pine, FL | Nonprofit | Jan 21, 2015 | Inactive |
| LOWER KEYS CONSTRUCTION WORKERS ASSOCIATION, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Jun 25, 2015 | Inactive |
| MONROE COUNTY LONG TERM RECOVERY GROUP, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Aug 9, 2018 | Inactive |
| LOWER KEYS MAJOR BASEBALL LEAGUE, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Mar 24, 1987 | Inactive |
| LISA'S HEART, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Apr 14, 2020 | Inactive |
| ATLANTIS ESTATES CANAL GATE PROPERTY OWNERS ASSOCIATION, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Apr 20, 1987 | Inactive |
| KEY WEST RADIOBig Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Oct 25, 2021 | Inactive |
| NO NAME KEY CANAL RESTORATION ASSOCIATION, INC.No Name Key, FL · Active | No Name Key, FL | Nonprofit | May 2, 2022 | Active |
| BIG PINE KEY JUDO CLUB, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Sep 29, 1987 | Inactive |
| PATRIOT HILLS OF NEW YORK, INC.Big Pine Key, FL · Active | Big Pine Key, FL | Nonprofit | Feb 20, 2023 | Active |
| KEYS FAMILY MANAGEMENT INCBig Pine Key, FL · Active | Big Pine Key, FL | Nonprofit | Jan 12, 2023 | Active |
| V.G.L HELPING HANDS CORPORATIONBig Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Jul 12, 2023 | Inactive |
| KEY WEST COMMUNITY RADIO INC.Location not reported, FL · Inactive | Location not reported, FL | Nonprofit | Oct 11, 2023 | Inactive |
| SAVE-A-TURTLE, INC.Big Pine Key, FL · Active | Big Pine Key, FL | Nonprofit | Dec 14, 1987 | Active |
| STEEL DRUM BAND OF THE FLORIDA KEYS, INC.Big Pine Key, FL · Active | Big Pine Key, FL | Nonprofit | May 22, 2024 | Active |
| SUNRISE DRIVE PROPERTY OWNERS, INC.Big Pine Key, FL · Inactive | Big Pine Key, FL | Nonprofit | Apr 6, 1988 | Inactive |
| KW MENS SOFTBALL CORPORATIONBig Pine Key, FL · Active | Big Pine Key, FL | Nonprofit | Jan 15, 2026 | Active |
| BIG PINE KEYS COMMUNITY CHURCH INCBig Pine Key, FL · Active | Big Pine Key, FL | Nonprofit | Jan 14, 2026 | Active |
| V.G.L HELPING HANDS CORPORATIONBig Pine Key, FL · Active | Big Pine Key, FL | Nonprofit | Jun 26, 2026 | Active |